Diagnostic-Powered Therapeutics for Brain Health
Gryphon Bio is an early-stage company created to harness our co-founders' discovery of unexpected waves of 1000s of brain molecules in the blood as novel therapeutic targets and temporal blood biomarkers (brain-specific proteins with blood levels that change over time like waves in the ocean). They made these discoveries over more than 20 years of “brain proteomic” research, the large-scale measurement of proteins in the brain.
Mission: To develop and market the first diagnostic-powered therapeutics for brain health.
Vision: To pioneer diagnostic-powered therapeutics to improve the lives of patients.
We are researching a promising, diversified pipeline of large molecule medicines, known as biologics, by following clues from nature’s sequence of cellular and molecular events for CNS repair. Each biologic has a unique mechanism(s) of action (MOA) and pharmacokinetic/pharmacodynamic (PK/PD) profile, compelling biology, and binds to a novel or de-risked therapeutic target(s).
Development of these and other diagnostic-powered therapeutics will be performed by a wholly owned subsidiary of Gryphon Bio: Owl Therapeutics, LLC.
Virtual clinical trials, where blood specimens and cognitive assessments can be collected both in the hospital and at home or in the field, guide the development of our temporal CNS blood biomarkers and biologics. In the future, we envision close engagement with our patient communities to assess needs and to develop artificial intelligence-based telemedicine solutions for brain health.
Novel blood tests based on temporal CNS blood biomarkers should improve the care, management, and hospitalization of our courageous patients. Potential indications of use should include screening for disease, predicting outcome, monitoring patients’ disease progression, and phenotyping individual trajectories to reconstruct and inform on key decisions (e.g., recovery, hospitalization, and return-to-work). Our novel blood tests should also improve the likelihood of regulatory approval of our biologics by health authorities.
OUR COURAGEOUS PATIENTS
CNS diseases are leading causes of death and disability, including:
Traumatic brain injury (TBI)
Alzheimer's disease (AD)
Neonatal Encephalopathy (NE)
Post-traumatic epilepsy (PTE)
Alexander's disease (AxD)
Alzheimer's disease related dementias (ADRD)
Multiple sclerosis (MS)
Brain metastatic breast cancer (bmBC)
Chronic traumatic encephalopathy (CTE)
Frontotemporal degeneration (FTD)
Spinal cord injury (SCI)
Non-Dilutive Funding (Grant Awards & Contracts)
Total Cash Raised
OUR COURAGEOUS TEAM
We are a proven, cohesive, interdisciplinary and internationally recognized team with deep experience in drug development (e.g., therapeutic bioconjugates), business development (e.g., licensing, intellectual property and partnerships) and CNS biomarker development (e.g., TBI). Together with our advisors, we have 1000+ previous peer-reviewed publications and $100M+ in previous grant awards. Moreover, we have successfully led several preclinical and clinical studies on successful high impact assets in industry and academe.
If you want to learn more about our amazing team members, get in touch.
WILL HASKINS, PHD
CEO & Co-Founder
Dr. William E. Haskins, Ph.D. (Co-Founder and CEO) in collaboration with Drs. Wang and Forsthuber, discovered unexpected waves of brain molecules in the blood as temporal biomarkers and therapeutic targets. He previously led teams for R&D of gene therapies, therapeutic antibody, and antibody-drug conjugates from Research through Phase I/II/III clinical trials for small and large biotechnology companies, including Genentech. Dr. Haskins is well-respected for developing and applying out-of-the-box solutions to challenging problems. He is highly experienced with analytical and bioanalytical chemistry, proteomics, bioinformatics, CNS biomarkers, and large molecule drug development (OCREVUS®, KADCYLA®, POLIVY®, etc.). He has authored or co-authored more than 73 peer-reviewed publications and numerous patents, and he is the Principal Investigator for several federal grant awards. Lastly, Dr. Haskins completed postdoctoral fellowships at the McKnight Brain Institute and Lawrence Livermore National Laboratories after earning his PhD in Bioanalytical Chemistry from the University of Florida in 2003.
OUR LATEST NEWS
Check our news section on a regular basis to always stay in the loop.
GRYPHON BIO RECEIVES NATIONAL INSTITUTES OF HEALTH GRANT AWARD TO ADVANCE CRITICAL RESEARCH IN TRAUMATIC BRAIN INJURY
September 11, 2021
South San Francisco, CA – Sunday, February 27, 2022– Gryphon Bio, Inc. today announced the Phase I component of more than $2.8M in National Institutes of Neurological Disorders and Stroke (NINDS)-sponsored research, part of the National Institutes of Health (NIH), for a Fast-Track SBIR award entitled “Temporal Biomarker-Powered Immunotherapy Targeting GFAP for Traumatic Brain Injury”. Traumatic brain injury (TBI) is a leading cause of mortality and morbidity around the world with approximately two million new patients each year in the US alone and no approved medicines. We hypothesize that immunotherapy with monoclonal antibodies (mAbs) will accelerate nature’s own mechanisms for devouring some of the most abundant and harmful brain cell debris that is released into the extracellular fluid of the brain during TBI. If successful, then mAb immunotherapy will be the first precision medicine to accelerate brain repair and improve cognition for TBI patients. According to Gryphon Bio CEO Will Haskins, “This grant award provides essential funding for the first digital health-powered immunotherapy for TBI patients.”